Method of adjusting the circadian rhythm of a mammal

Details Method of adjusting the circadian rhythm of a mammal Method of adjusting the circadian rhythm of a mammal

A - Human Necessities

61

K

A61K 31/54 (2006.01)

Patent

CA 2235803

A method of adjusting the circadian rhythm of a mammal comprising administering to said mammal an effective circadian rhythm adjusting amount of 6-methy-5-oxo-3-thiomorpholinylcarbonyl-L-histidyl-L-prolinamide or a pharmaceutically acceptable salt thereof. The method of the invention may be useful to assist shift workers to adjust to rotating work schedules, to alleviate the effects of jet-lag on travelers to remote time zone and/or to treat sufferers of delayed sleep phase syndrome.

L'invention concerne une méthode pour ajuster le rythme circadien d'un mammifère, ladite méthode consistant à administrer audit mammifère une quantité, suffisamment efficace pour ajuster le rythme circadien, de 6-méthyl-5-oxo-3-thiomorpholinylcarbonyl-L-histidyl-L-prolinamide ou d'un sel pharmaceutiquement acceptable dudit composé. Cette méthode peut s'utiliser pour aider les ouvriers postés à s'adapter à des horaires de travail tournants, pour atténuer les effets du décalage horaire chez les personnes qui voyagent vers des pays situés dans des fuseaux horaires éloignés et/ou pour traiter les personnes souffrant de décalage de la phase du sommeil.

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