A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/685 (2006.01) A61K 9/00 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01)
Patent
CA 2096537
A method of administering a surfactant dispersion to the lungs of a patient in need of such treatment is disclosed. The method comprises heating the dispersion and nebulizing the heated dispersion to produce respirable surfactant particles. The re- spirable surfactant particles are delivered to the lungs of the patient. By heating the dispersion the amount of phospholipid deliv- ered to the lungs of the patient is increased. The dispersion is comprised of a phospholipid dispersed in an aqueous carrier. In a particular embodiment of the invention, the phospholipid is preferably dipalmitoylphosphatidylcholine (DPPC) included in an amount from about 8 to 50 milligrams per milliliter of aqueous carrier, and the dispersion is preferably heated to a termperature between about 25 °C and 75 °C.
Davis Craig William
Snyder Rodney Gary
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The Wellcome Foundation Limited
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