A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/108 (2006.01) A61K 39/385 (2006.01) C07K 1/00 (2006.01) C07K 14/245 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2420234
The present invention relates to methods of stimulating an immune response in a primate utilizing compositions comprising bacterial adhesin proteins and/or immunogenic fragments thereof. The compositions are useful for the prevention and treatment of bacterial induced diseases involving bacterial adherence to a target cell, such as diseases of the urinary tract. More specifically, the invention relates to the vaccination of primates, preferably humans, with protein complexes, such as a purified FimH polypeptides, a purified FimC- FimH(FimCH) polypeptide complex, or immunogenic fragments thereof, to stimulate protective immunity in the recipient against infection by pathogenic bacteria, including all types of Enterobacteriaceae, preferably E. coli to produce specific immunoglobin molecules in the serum and urine or mucosal secretions of the subject.
L'invention concerne des méthodes permettant de stimuler une réponse immunitaire chez un primate au moyen de compositions comprenant des protéines adhésines bactériennes et/ou des fragments immunogènes de ces dernières. Lesdites compositions sont utiles pour la prévention et le traitement de maladies provoquées par des bactéries comprenant une adhérence bactérienne sur une cellule cible, telles que des maladies des voies urinaires. D'une manière plus spécifique, l'invention concerne la vaccination de primates, de préférence des êtres humains, au moyen de complexes de protéines, tels que des polypeptides FimH purifiés, un complexe polypeptide purifié FimC-FimH(FimCH) ou des fragments immunogènes de ces derniers, afin de stimuler une immunité de protection chez le receveur contre une infection aux bactéries pathogènes, notamment tous les types de Enterobacteriaceae, de préférence E. coli, afin de produire des molécules d'immunoglobuline spécifiques dans le sérum et les sécrétions urinaires ou muqueuses du sujet.
Ballou W. Ripley
Langermann Solomon
Medimmune Inc.
Osler Hoskin & Harcourt Llp
LandOfFree
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