Method of administering narcotic antagonists and analgesics...

Details Method of administering narcotic antagonists and analgesics... Method of administering narcotic antagonists and analgesics...

Category

A - Human Necessities

Subcategory

61

Subsubcategory

K

CPC

167/227, 167/244

IPC codes

A61K 31/485 (2006.01) A61K 9/00 (2006.01) A61K 31/35 (2006.01)

Type

Patent

Patent number

CA 1183778

Description

ABSTRACT The invention provides a novel method of administering narcotic antagonists, narcotic analgesics and related compounds, and dosage forms containing those compounds which are adapted for nasal admini- stration. The nasal dosage forms disclosed include solutions, suspensions, gels and ointments. The compound administered can be morphine or an analogue thereof bearing at least one phenolic hydroxyl substituent and having narcotic analgesic, antagonist or agonist-antagonist activity, or .DELTA.9-tetrahydrocannabinol or a pharmacologically active analogue thereof bearing at least one phenolic hydroxyl substituent. Especially preferred compounds which can be advantageously administered in accordance with the invention include naloxone, naltrexone, nalbuphine, levorphanol, buprenorphine, butorphanol, .DELTA.9-tetrahycrocannabinol (THC), cannabidiol (CBD) and levonantradol. The novel dosage forms of the invention include nasal ointments, nasal gels and isotonic nasal compositions containing the selected compound in the form of the free base, or in the case of morphine and its analogues, optionally in the form of a nontoxic pharmaceutically acceptable acid addition salt; and sustained release nasal dosage forms containing a long chain carboxylic acid salt of morphine or an analogue thereof.

Application Number

401775

Affiliated with

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