Method of administration of igf-i

Details Method of administration of igf-i Method of administration of igf-i

A - Human Necessities

61

K

A61K 38/30 (2006.01) A61K 38/55 (2006.01)

Patent

CA 2218018

A method is disclosed that comprises administering insulin-like growth factor- I (IGF-I) to a mammal so as to sustain its biological activity in the mammal comprising administering a therapeutically effective amount of IGF-I to the mammal to provide an exposure to IGF-I for a period of time that stimulates the maximum biological response in the mammal, then discontinuing said administration for a period of time equal to or less than the time period used for administration, and repeating this pattern of administration and discontinuance of administration for a period as long as necessary to achieve or maintain the desired biological response in the mammal.

On décrit un procédé d'administration du facteur de croissance insulinoïde I (IGF-I) à un mammifère pour favoriser son activité biologique. Dans ce procédé, on administre à un mammifère une dose d'IGF-I thérapeutique efficace pour obtenir une exposition à l'IGF-I pendant une durée suffisante pour stimuler d'une manière optimale la réponse biologique de ce mammifère. Ensuite, l'administration est interrompue pendant une durée équivalente à la durée d'administration, ou moindre. Ce processus d'administration et de non administration est répété, pendant la durée nécessaire pour obtenir ou maintenir la réponse biologique souhaitée sur l'animal.

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