Method of altering cell properties by administering rna

Details Method of altering cell properties by administering rna Method of altering cell properties by administering rna

A - Human Necessities

61

K

A61K 48/00 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2531242

The invention relates to the alteration of cell properties using RNA molecules. In particular, it relates to the alteration of the ability of cells to mobilise, migrate, integrate, proliferate and/or differentiate. For example, it relates to the induction of differentiation of stem cells, including the acquisition of the ability to migrate, integrate, and proliferate. It also relates to the induction of in vivo stem cell mobilisation, migration, integration, proliferation and/or differentiation. Accordingly, it relates to the promotion of stem cell-mediated functional repair. The invention also relates to the reversal of differentiation of differentiated cells. All these effects may be effected by providing isolated RNA comprising a RNA sequence extractable from cells comprising the desired cell type(s) to a population of cells under conditions whereby the alteration of the cell property is achieved.

L'invention se rapporte à la modification de propriétés de cellules au moyen de molécules d'ARN. En particulier, elle se rapporte à la modification de la capacité des cellules à mobiliser, migrer, intégrer, proliférer et/ou différencier. Par exemple, l'invention se rapporte à l'induction de la différenciation de cellules souches, et notamment à l'acquisition de la capacité à migrer, intégrer et proliférer. Elle se rapporte également à l'induction de la mobilisation, migration, intégration, prolifération et/ou différenciation dans des cellules souches <i>in vivo</i>. L'invention se rapporte par conséquent à la possibilité de promouvoir la réparation fonctionnelle médiée par des cellules souches. L'invention se rapporte en outre à l'inversion de la différenciation de cellules différenciées. Il est également possible d'obtenir tous ces effets en fournissant de l'ARN isolé comportant une séquence d'ARN pouvant être extraite de cellules comprenant le ou les types de cellules souhaités à une population de cellules, dans des conditions permettant d'obtenir la modification de la propriété des cellules.

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