Method of altering the binding specificity of plasma...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 16/00 (2006.01) A61K 39/395 (2006.01) B01D 57/02 (2006.01) C07K 1/113 (2006.01) C07K 1/24 (2006.01) C07K 1/26 (2006.01) G01N 33/561 (2006.01) G01N 33/564 (2006.01)

Patent

CA 2524325

The binding specificity of at least one plasma protein suspended or dissolved in a liquid medium it altered by exposing the protein to an oxidizing agent or an electric current sufficient to alter its binding specificity. A masked protein such as an autoantibody can be recovered from blood or blood products or extracts by oxidizing the protein to change its binding specificity.

La spécificité de liaison d'au moins une protéine plasmique suspendue ou dissoute dans un milieu liquide est modifiée par exposition de cette protéine à un agent oxydant ou à un courant électrique suffisant pour modifier sa spécificité de liaison. Une protéine masquée, telle qu'un auto-anticorps, peut être récupérée à partir du sang ou de produits sanguins ou extraite par oxydation de ladite protéine afin de modifier sa spécificité de liaison.

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