Method of analyzing aminofunctional compound and analytical...

Details Method of analyzing aminofunctional compound and analytical... Method of analyzing aminofunctional compound and analytical...

G - Physics

01

N

G01N 27/62 (2006.01) G01N 30/72 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2475011

It is intended to provide a method of conveniently and highly sensitively analyzing an aminofunctional compound such as an amino acid or a peptide contained in a sample. The aminofunctional compound in the aminofunctional compound-containing sample as described above is conveniently and highly sensitively analyzed by labeled the aminofunctional compound with a specific carbamate compound such as p-trimethylammonium anilyl-N-hydroxysuccinimide carbamate iodide to thereby enhance the selectivity. This method is usable particularly in quantitatively analyzing a target compound by a mass spectrometric analysis method such as the MS/MS method. It is also intended to provide a labeling reagent for the mass spectrometric analysis and a novel compound which can be used in this labeling reagent.

L'invention concerne un procédé permettant d'analyser de manière appropriée et hautement sensible un composé aminofonctionnel, tel qu'un acide aminé ou un peptide, contenu dans un échantillon. Le composé aminofonctionnel d'un échantillon est analysé, de manière appropriée et hautement sensible, par marquage de ce composé aminofonctionnel à l'aide d'un composé de carbamate spécifique, tel qu'un iodure de triméthylammonium anilyl-N-hydroxysuccinimide carbamate, ce qui permet d'améliorer la sélectivité. Ce procédé est particulièrement utile pour analyser quantitativement un composé cible au moyen d'un procédé d'analyse par spectrométrie de masse tel que le procédé MS/MS. L'invention concerne également un réactif de marquage destiné à une analyse par spectrométrie de masse et un nouveau composé pouvant être utilisé avec ledit réactif de marquage.

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