Method of assuming drug sensitivity to cdk4 inhibitor

C - Chemistry – Metallurgy – 12 – N

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C12N 15/09 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2575986

It is intended to provide a gene for assuming drug sensitivity, which is to be used for assuming the drug sensitivity to a CDK4 inhibitor based on the expression amount in a test tissue or a test cell, selected from the group consisting of p16 gene, p18 gene and p27 gene. It is also intended to provide a method of assuming the drug sensitivity to a CDK4 inhibitor by using the expression amount of the above gene in a test tissue or a test cell as an indication.

L'invention concerne un gène servant à évaluer la sensibilité à un médicament, lequel gène doit être utilisé pour évaluer la sensibilité à un médicament en tant qu'inhibiteur de la CDK4 sur la base de la quantification de l'expression du gène dans un tissu testé ou une cellule testée, lequel gène est sélectionné dans le groupe constitué du gène p16, du gène p18 et du gène p27. L'invention concerne également un procédé d'évaluation de la sensibilité à un médicament en tant qu'inhibiteur de la CDK4 en utilisant comme indication la quantification de l'expression du gène ci-dessus dans un tissu testé ou une cellule testée.

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