Method of attenuating graft rejection

Details Method of attenuating graft rejection Method of attenuating graft rejection

A - Human Necessities

61

K

A61K 31/275 (2006.01) A61K 31/436 (2006.01) A61K 31/522 (2006.01) A61K 31/573 (2006.01)

Patent

CA 2482039

The invention provides a method of attenuating graft rejection in a patient undergoing an organ or tissue transplantation procedure. The inventive method involves administering FK778 using a dosing regimen that includes a period of customized administration to achieve or approximate a target whole blood trough level of FK778. The regimen optionally includes administration of a calcineurin inhibitor, such as Tacrolimus, and/or a steroid, and/or an antiviral. Specific preferred quantities of these pharmaceutically-active agents are provided as well as preferred timing and routes of administration. The invention also provides a medical kit for administering FK778. The kit includes printed instructions for administering FK778 to the patient undergoing a graft transplantation procedure according to a dosing regimen containing a period during which the dosage of FK778 is adjusted to deliver an amount of FK778 sufficient to maintain a target whole blood though level of FK778, such as described herein. The kit also contains a supply of FK778 in dosage units suitable for use in the inventive method.

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