Method of attenuating reactions to skin irritants

Details Method of attenuating reactions to skin irritants Method of attenuating reactions to skin irritants

A - Human Necessities

61

K

A61K 31/66 (2006.01) A61K 8/55 (2006.01) A61K 8/68 (2006.01) A61K 31/00 (2006.01) A61K 31/164 (2006.01) A61K 31/685 (2006.01) A61K 31/70 (2006.01) A61K 31/739 (2006.01) A61K 31/765 (2006.01) A61Q 17/00 (2006.01) A61Q 19/00 (2006.01)

Patent

CA 2441893

The present invention is directed to a method of inhibiting CD1d activation by administering a composition containing a moiety that blocks CD1d activation. Compositions of the invention are useful for the attenuation of CD1d- restricted immune responses, including treatment of skin disorders due to hyperactive immune responses (e.g., contact hypersensitivity), for systemic administration to attenuate ongoing immune responses, and to provide hypoallergenic cosmetic products including pharmaceutical, cosmetic, and skin care compositions. Preferably, these compositions are in a form intended for topical administration.

La présente invention concerne une méthode permettant d'inhiber l'activation de CD1d par administration d'une composition contenant un fragment bloquant l'activation de CD1d. Les compositions décrites dans cette invention peuvent être utilisées pour atténuer les réponses immunitaires limitées au CD1d, y compris le traitement de troubles cutanés provoqués par des réponses immunitaires hyperactives (par exemple, l'hypersensibilité de contact), elles peuvent être utilisées pour une administration systémique afin d'atténuer les réponses immunitaires en cours et pour obtenir des produits cosmétiques hypoallergéniques, y compris des compositions pharmaceutiques, des compositions cosmétiques et des compositions de soin de la peau. De préférence, ces compositions se présentent sous une forme permettant une administration topique.

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