Method of binding material to the .beta.-amyloid peptide

Details Method of binding material to the .beta.-amyloid peptide Method of binding material to the .beta.-amyloid peptide

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/08 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2174501

The present invention relates to the finding that antibodies bind to the .beta.-amyloid peptide, and that .beta.-amyloid peptide binds the hinge region of the immunoglobulin heavy chain, thereby preserving the ability of the immunoglobulin to bind antigen. Methods for binding compounds such as detectable groups to .beta.-amyloid peptide are accordingly presented.

L'invention concerne la découverte que des anticorps se lient au peptide .beta.-amyloïde et que celui-ci se lie à la région charnière de la chaîne lourde des immunoglobulines, ce qui préserve pour ces immunoglobulines la possibilité de se lier à un antigène. On présente en conséquence des procédés qui permettent de lier des composés tels que des groupes détectables au peptide .gamma.-amyloïde.

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