Method of chain combination

Details Method of chain combination Method of chain combination

C - Chemistry, Metallurgy

07

K

530/7.1

C07K 14/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1336223

Production of human relaxin or novel human relaxin analogs by combination of a human relaxin A-chain and B-chain comprising combining the reduced form of the human relaxin A-chain and the reduced form of the human relaxin B-chain in an aqueous medium having a pH of from about 7.0 to 12 at room temperature, under conditions that are mildly denaturing for the relaxin B-chain such that the human relaxin or novel human relaxin analog can be formed.

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