Method of cleaving specific strands of rna

Details Method of cleaving specific strands of rna Method of cleaving specific strands of rna

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2147282

A method of using a chimeric molecule made up of an antisense oligonucleotide attached to a 2',5'-oligoadenylate molecule to specifically cleave a sense strand of RNA, wher- ein the antisense oligonucleotide of the chimeric molecule is hybridized to the sense strand of RNA in the presence of 2', 5'-dependent RNase.

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