A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/04 (2006.01) A61K 31/195 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/52 (2006.01) A61K 31/535 (2006.01)
Patent
CA 2095408
Method of Combating Acyclovir-resistant Herpes Simplex Viral Infections Abstract of the Disclosure Disclosed herein is a method for treating acyclovir-resistant herpes infections in a mammal. The method comprises administering a peptide derivative or a combination of the peptide derivative and an antiviral nucleoside analog to the infected mammal. The peptide derivative used for the method is represented by the formula A-B-D- CH2CH{CH2C(O)R1}C(O)-NHCH{CR2(R3)COOH}C(O)-E wherein A is a terminal group, for example an optionally substituted phenylalkanoyl, and B is a N-methyl amino acid residue; or A and B together form a saturated alkylaminocarbonyl; D is an amino acid residue; R2 is, for example, an alkyl, cycloalkyl, or a monosubstituted or a disubstituted amino; R2 is, for example, hydrogen or alkyl and R3 is alkyl, or R2 is hydrogen and R3 is phenylalkyl, or R2 and R3 are joined to from a cycloalkyl; and E is a terminal unit, for example, an alkylamino or a monovalent amino acid radical such as NHCH(alkyl)C(O)OH.
Chafouleas James Gus
Deziel Robert
Bio-Mega/boehringer Ingelheim Research Inc.
Boehringer Ingelheim (canada) Ltd. Boehringer Ingelheim (canada)
Swabey Ogilvy Renault
LandOfFree
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