Method of controlling telomere length

Details Method of controlling telomere length Method of controlling telomere length

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A61K 35/76 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07H 21/00 (2006.01) C07K 14/395 (2006.01) C12N 9/16 (2006.01) C12N 9/22 (2006.01)

Patent

CA 2400263

A method of controlling the length of a telomere characterized by transferring into the cell a DNA encoding Mrell protein or a DNA encoding a protein derived from Mrell protein by modification or deletion of a part of the nuclease domain and C-terminal domain or the whole thereof.

L'invention concerne un procédé de contrôle de la longueur d'un télomère, qui consiste à transférer dans la cellule une protéine Mrell codant l'ADN ou bien de l'ADN codant une protéine dérivée de la protéine Mrell par modification ou suppression de tout ou partie du domaine de nucléase et du domaine C-terminal.

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