Method of controlling the size of liposomes

Details Method of controlling the size of liposomes Method of controlling the size of liposomes

B - Operations, Transporting

01

J

B01J 13/02 (2006.01) A61K 9/127 (2006.01) A61K 31/557 (2006.01) A61K 31/71 (1995.01)

Patent

CA 2166465

A process for producing a population of liposomes using lipid in a single- phase solvent system wherein the liposomes have a desired mean particle size, the process comprising testing the size of a test population of liposomes at a test solvent concentration; and forming a population of liposomes by adding to the lipid a concentration of solvent selected to form the desired mean particle size.

Ce procédé destiné à produire une population de liposomes utilise un lipide contenu dans un système solvant monophase dans lequel les liposomes ont une taille moyenne de particule conforme à une spécification. Le procédé comporte, à une concentration test de solvant, des opérations de vérification de la taille d'une population test de liposomes. Le procédé comporte également la formation d'une population de liposomes par adjonction au lipide d'une concentration de solvant choisie pour obtenir la taille moyenne désirée pour les particules.

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