Method of controlling weight gain associated with...

Details Method of controlling weight gain associated with... Method of controlling weight gain associated with...

A - Human Necessities

61

K

A61K 31/135 (2006.01) A61K 31/137 (2006.01) A61P 3/04 (2006.01)

Patent

CA 2367021

A compound of formula (I), or a pharmaceutically acceptable salt thereof in which R1 and R2 are independently H or methyl (for example <u>N</u>,<u>N</u>- dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl amine hydrochloride optionally in the form of its monohydrate) is used for treating weight gain associated with treatment with certain drug therapy, including the use of tricyclic antidepressants, lithium, sulphonylureas, beta-adrenergic blockers, certain steroid contraceptives, corticosteroids, insulin, cyproheptadine, sodium valproate, neuroleptics, phenothiazine or piztifen.

L'invention concerne un composé correspondant à la formule (I), ou un sel de celui-ci, acceptable sur le plan pharmacologique. Dans cette formule, R¿1? et R¿2? représentent indépendamment H ou méthyle (par exemple du chlorhydrate de <u>N</u>,<u>N</u>-diméthyl-1-[1-(4-chlorophényl)cyclobutyl]-3-méthylbutylamine, éventuellement sous la forme de son monohydrate). Ce composé est utile pour traiter le gain de poids associé au traitement par certains médicaments, notamment le traitement à l'aide d'antidépresseurs tricycliques, de lithium, de sulfamides hypoglycémiants, de bêtabloquants, de certains contraceptifs stéroïdes, de corticostéroïdes, d'insuline, de cyproheptadine, de valproate de sodium, de neuroleptiques, de phénothiazine ou de piztifène.

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