Method of creating and searching a molecular virtual library...

G - Physics – 06 – F

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G06F 17/00 (2006.01) G06F 17/50 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2245935

The problem of how to select out of a large chemically accessible universe molecules representative of the diversity of that universe is resolved by the discovery of a method to validate molecular structural descriptors. Using the validated descriptors, optimally diverse subsets (5) can be selected. In addition, from the universe, molecules with characteristics similar to a selected molecule can be identified (3). The validated descriptors also enable the generation of a huge virtual library of potential product molecules which could be formed by combinatorial arrangement of structural variations and cores. In this virtual library it is possible to search billions of possible product compounds in relatively short time frames.

Le problème de la sélection de molécules dans l'univers étendu des molécules chimiques possibles, dans toute sa diversité, est résolu par la découverte d'un procédé permettant de valider des descripteurs de structure moléculaire. En utilisant les descripteurs validés, on peut sélectionner des sous-ensembles (5) diversifiés de manière optimale. En plus, on peut identifier (3) dans cet univers des molécules possédant des caractéristiques similaires à celles d'une molécule sélectionnée. Les descripteurs validés permettent, également, de produire une bibliothèque virtuelle immense de molécules potentielles de produits qui peuvent être formées par arrangement combinatoire de différentes structures et noyaux. Dans cette bibliothèque virtuelle, il est possible d'effectuer une recherche parmi des milliards de composés possibles de produits, en un temps relativement court.

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