Method of decreasing radiation or radio-mimetic chemotherapy...

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/18 (2006.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61K 38/19 (2006.01)

Patent

CA 2227241

The present invention provides a method of engrafting donor mammalian hematopoietic pluripotent tolls in a mammalian recipient using a decreased amount of radiation, comprising: (a) administering to the recipient at least one dosage of a hematopoietic growth factor, (b) subjecting the recipient to a low dosage of radiation; and (c) transplanting the donor hematopoietic pluripotent cells into the recipient, thereby engrafting the donor mammalian hematopoietic pluripotent cells in the mammalian recipient using a decreased amount of radiation. The invention also provides a method of engrafting donor mammalian hematopoietic pluripotent cells in a mammalian recipient using a decreased amount of radiomimetic compound, comprising: (a) administering to the recipient at least one dosage of a hematopoietic growth factor; (b) subjecting the recipient to a low dosage of radiomimetic compound; and (c) transplanting the hematopoietic pluripotent cells into the recipient, thereby engrafting the donor mammalian hematopoietic pluripotent cells in the mammalian recipient using a decreased amount of radiomimetic compound.

L'invention concerne une méthode pour greffer les cellules hématopoïétiques pluripotentes d'un mammifère donneur chez un mammifère receveur utilisant une dose réduite de rayons, comprenant: a) l'administration au receveur d'au moins une posologie d'un facteur de croissance hématopoïétique; b) le traitement du receveur avec une faible dose de rayons; et c) la transplantation des cellules hématopoïétiques pluripotentes du donneur chez le receveur, ladite greffe faisant appel à une dose réduite de rayons. L'invention concerne également une méthode pour greffer les cellules hématopoïétiques pluripotentes d'un mammifère donneur chez un mammifère receveur utilisant une dose réduite d'un composé radio-mimétique, comprenant: a) l'administration au receveur d'au moins une posologie d'un facteur de croissance hématopoïétique; b) l'administration au receveur d'une faible posologie d'un composé radio-mimétique; c) la transplantation des cellules hématopoïétiques pluripotentes du donneur chez le receveur, ladite greffe de cellules pluripotentes hématopoïétiques chez le mammifère receveur faisant appel à une dose réduite de composé radio-mimétique.

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