Method of defining the differentiation grade of tumor

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2521876

The present invention relates to a method of defining the differentiation grade of tumor by selecting genes and/or proteins whose expression level correlates with each differentiation grade of tumor, measuring the expression of the genes and/or proteins of human tumor tissues in each differentiation grade. The present invention also relates to the use of these genes and/or proteins for diagnosing the differentiation grade of tumor and for screening anti-cancer agents for tumor treatment.

La présente invention se rapporte à un procédé de définition du degré de différenciation d'une tumeur, qui consiste à sélectionner des gènes et/ou des protéines dont le niveau d'expression est corrélé à chaque degré de différenciation d'une tumeur, à mesurer l'expression des gènes et/ou protéines des tissus tumoraux d'origine humaine à chaque degré de différenciation. La présente invention se rapporte également à l'utilisation de ces gènes et/ou protéines pour évaluer le degré de différenciation d'une tumeur et pour cribler des agents anticancéreux permettant le traitement de la tumeur.

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