Method of delivering genes to antigen presenting cells of...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 39/00 (2006.01) A61K 39/21 (2006.01) A61K 47/48 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2302316

A molecular delivery complex specific to antigen-presenting cells is formed from a non-viral gene delivery system complexed with foreign genetic material. The complex then enters the targeted cells through a specific receptor and overcomes the degradation mechanism, so that functional uptake of the foreign genetic material, or transduction, of the cell, results in gene expression. The invention also includes a method for genetic immunization without a needle.

La présente invention concerne un complexe moléculaire d'administration spécifique à des cellules présentant des antigènes. Ledit complexe est constitué à partir d'un système d'administration de gène non viral formant des complexes avec une matière génétique étrangère. Le complexe entre, ensuite, dans les cellules ciblées par l'intermédiaire d'un récepteur spécifique et surmonte le mécanisme de dégradation de sorte que l'absorption fonctionnelle de la matière génétique étrangère ou la transduction de la cellule provoque une expression génique. La présente invention concerne également un procédé d'immunisation génétique sans aiguille.

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