Method of delivering rna interference and uses thereof

Details Method of delivering rna interference and uses thereof Method of delivering rna interference and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2576925

The invention provides a method of RNA interference, which comprises contacting the cell with a fusion protein-double stranded RNA complex, the complex comprising the double stranded RNA segment containing a double stranded RNA of interest and a fusion protein, the fusion protein comprising (1) a targeting moiety, which will specifically binds to a site on a target cell, and (2) a binding moiety, which will bind to the double stranded RNA, wherein the double stranded RNA segment initiates RNA interference in the cell.

L'invention concerne une méthode d'interférence ARN, consistant à mettre en contact une cellule avec un complexe protéine de fusion-ARN double brin, le complexe comprenant le segment d'ARN double brin contenant un ARN double brin d'intérêt et une protéine de fusion, la protéine de fusion comprenant (1) un fragment de ciblage lié de manière spécifique à un site de la cellule cible, et (2) un fragment de liaison lié à l'ARN double brin, le segment d'ARN double brin activant l'interférence ARN dans la cellule.

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