Method of designing agonists and antagonists to igf receptor

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/705 (2006.01) C07K 14/65 (2006.01) C07K 14/71 (2006.01) G06F 17/50 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2311926

The present invention relates to a method of designing compounds able to bind to a molecule of the insulin receptor family and to modulate the activity mediated by the receptor based on the 3-D structure coordinates of a IGF-1 receptor crystal of Figure 1.

Cette invention se rapporte à un procédé permettant de mettre au point des composés capables de se fixer à une molécule de la famille des récepteurs d'insuline et de moduler l'activité induite par le récepteur sur la base des coordonnées de la structure tridimensionnelle d'un cristal du récepteur de l'IGF-1 (facteur de croissance proche de l'insuline-1) représenté par la figure 1.

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