Method of detecting and analysing paclitaxel-mimetic compounds

Details Method of detecting and analysing paclitaxel-mimetic compounds Method of detecting and analysing paclitaxel-mimetic compounds

G - Physics

01

N

G01N 33/50 (2006.01) G01N 33/566 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2454396

A large portion of cytostatics, including paclitaxel (Taxol®) and other recently-discovered substances which mimic the antitumor effects thereof, have cellular microtubules by way of a target. The present invention relates to a high-throughput homogenous analysis which is based on the use of stabilised microtubules and fluorescent taxoids and which is used to detect any substances that can substitute paclitaxel at the site where paclitaxel binds to the microtubules and that constitute potential anticancer agents.

Une grande partie des cytostatiques, y compris le paclitaxel (Taxol ®) et d'autres substances découvertes récemment qui reproduisent ses effets antitumoraux, ont pour cible les microtubules cellulaires. La présente invention concerne une analyse homogène à haut rendement, reposant sur l'utilisation de microtubules stabilisés et de taxoïdes fluorescents, destinée à la détection de substances pouvant substituer le paclitaxel au niveau de son site de fixation sur les microtubules et constituer des agents anticancéreux potentiels.

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