Method of detecting and reducing boar taint using nuclear...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/16 (2006.01) A61K 31/395 (2006.01) A61K 31/4166 (2006.01) A61K 31/575 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 5/00 (2006.01) A61P 5/24 (2006.01) C07K 14/72 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2633296

A method for preventing or reducing boar taint, a method of screening pigs to determine those more likely to have reduced boar taint and a method for screening substances that enhance skatole metabolism or androstenone in a pig, are disclosed These methods involve the use of the nuclear receptors constitutive androstane receptor, pregnane X receptor and farnesoid X receptor, which have been found to modulate the activity of the enzymes involved in skatole and/or androsterone metabolism

L'invention concerne une méthode pour empêcher ou réduire le mauvais goût de porc, une méthode pour sélectionner des porcs afin de déterminer ceux ayant la plus forte probabilité d'avoir un mauvais goût réduit, et une méthode pour détecter des substances qui rehaussent le métabolisme du scatole ou de l'androstérone chez un porc. Ces méthodes impliquent l'utilisation de récepteurs nucléaires constitutifs du récepteur androstane, des récepteurs nucléaires orphelins PXR (pregnane X receptor) et FXR (farnesoid X receptor) qui sont connus pour moduler l'activité des enzymes impliqués dans le métabolisme de l'androstérone et/ou du scatole

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