C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/64 (2006.01) C07K 7/08 (2006.01) C40B 30/04 (2006.01) G01N 33/564 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2489167
The invention relates to method of detecting autoantibodies from patients suffering from rheumatoid arthritis. To this end, according to the invention, at least two peptide units are used of which at least one peptide unit comprises a part not derived from (pro)fillaggrin, fibrin, fibrinogen, vimentin, cytokeratin 1 and cytokeratin 9, and which peptide unit comprises the motif XG, and a peptide unit comprising the motif XnonG, wherein X is a citrullin or an analogue thereof, and nonG is an amino acid other than glycine.
L'invention concerne un procédé pour détecter des auto-anticorps chez des patients souffrant de polyarthrite rhumatoïde. Selon l'invention, au moins deux unités peptidiques sont utilisées, dont une au moins comporte une portion non dérivée de la (pro)fillagrine, de la fibrine, du fibrinogène, de la vimentine, de la cytokératine 1 ou de la cytokératine 9, ladite portion contenant le motif XG. On utilise aussi une unité peptidique comprenant le motif XnonG, dans lequel X représente une citrulline ou une substance analogue et nonG signifie un acide aminé différent de la glycine.
Drijfhout Jan Wouter
Pruijn Gerardus Jozef Maria
Van Boekel Martinus Adrianus Maria
Van Venrooij Waltherus Jacobus Wilhelmus
Smart & Biggar
Stichting Voor de Technische Wetenschappen
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