C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2552553
A method of detecting liver cancer whereby liver cancer can be highly specifically detected; a diagnostic therefor; and a novel remedy for cancer having an excellent anticancer effect. In this method for detecting liver cancer cells in a sample, use is made of the expression of dlk gene as an indication. The expression of the dlk gene can be assayed by an immunoassay with the use of anti-dlk antibody or an assay of mRNA of the dlk gene. The remedy for cancer contains, as the active ingredient, an antibody undergoing an antigen-antibody reaction with Dlk expressed on caner cell surface and exhibiting an anticancer effect on the cancer cells.
L'invention porte sur une méthode de détection extrêmement spécifique du cancer du foie, sur une méthode diagnostique et sur un nouveau remède ayant un excellent effet anticancéreux. Dans ce procédé de détection des cellules cancéreuses du foie d'un échantillon, on utilise l'expression du gène dlk comme indication. L'expression du gène dlk peut être analysée au moyen d'un dosage immunologique avec un anticorps anti dlk ou un dosage d'ARNm du gène dlk. Le remède anticancéreux contient, comme ingrédient actif, un anticorps subissant une réaction antigène-anticorps avec dlk exprimé sur la surface des cellules cancéreuses et ayant un effet anticancéreux sur lesdites cellules.
Anzai Hiroko
Miyajima Atsushi
Nakamura Koji
Yanai Hiroyuki
Kanagawa Academy Of Science And Technology
Smart & Biggar
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