Method of detecting t-cell activation

Details Method of detecting t-cell activation Method of detecting t-cell activation

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/532 (2006.01) G01N 33/564 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2335749

Methods of detecting activated T-cells involve monitoring levels of MUC-1 mucin expression at the protein and/or mRNA level. Compositions for modulating immune function contain compounds that modulate the expression or function of MUC-1. Methods of treating disorders associated an inappropriate state of T- cell activation involve contacting a T-cell with a compound containing an inhibitor of MUC-1 expression or function.

Procédés de détection de lymphocytes T activés qui impliquent la surveillance des niveaux d'expression de mucine MUC-1 au niveau protéique et/ou de l'ARNm. Des compositions destinées à moduler la fonction immunitaire contiennent des composés qui modulent l'expression ou la fonction de MUC-1. Des procédés de traitement de troubles associés à un état inapproprié d'activation des lymphocytes T consistent à mettre en contact un lymphocyte T avec un composé contenant un inhibiteur de la fonction ou de l'expression de MUC-1.

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