Method of determination of pivka of every kind and reagent...

C - Chemistry – Metallurgy – 12 – P

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C12P 21/08 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) G01N 33/82 (2006.01)

Patent

CA 2121927

Abstract To provide a simple immunochemical assay of a PIVKA of every kind (PIVKA-VII, -IX, -X, -C, -S or -Z; protein induced by vitamin K absence) corresponding to a vitamin K-dependent protein. It has been confirmed that a PIVKA of every kind can be determined according to the double antibody sandwich method wherein use is made of a solid-supported anti-PIVKA-II monoclonal antibody. There is also disclosed a reagent for determination of a PIVKA of every kind according to the above-mentioned method. - 33 -

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