C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/7068 (2006.01) A61K 33/24 (2006.01) A61P 35/00 (2006.01) C12N 15/09 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2437044
The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing ERCC1 expression levels in fixed or fixed and paraffin embedded tissues and determine a platinum-based chemotherapy by examination of the amount of ERCC1 mRNA in a patient's tumor cells and comparing it to a predetermined threshold expression level. More specifically, the invention provides to oligonucleotide primer pair ERCC1 and methods comprising their use for detecting levels of ERCC1 mRNA.
La présente invention concerne des procédés de pronostique utiles en médecine, notamment en traitement chimiothérapeutique du cancer. L'invention vise à fournir un procédé permettant d'évaluer des niveaux d'expression de ERCC1 dans des tissus fixés ou fixés et enrobés de paraffine et à déterminer un traitement chimiothérapeutique à base de platine par analyse du taux d'ARN m deERCC1 dans les cellules tumorales d'un patient puis à le comparer à un niveau d'expression seuil prédéterminé. L'invention concerne plus précisément une paire d'amorces oligonucléotidiques de ERCC1 et des procédés comportant leur utilisation pour détecter les niveaux d'ARNm de ERCC1.
Blake Cassels & Graydon Llp
Response Genetics Inc.
LandOfFree
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