Method of determining a phosphorus binder dosage for a...

G - Physics – 01 – N

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G01N 33/84 (2006.01)

Patent

CA 2739545

The invention is directed to a method of determining a dosage of phosphorus binder for a patient undergoing dialysis treatment to achieve a pre-dialysis serum phosphorus concentration within a desired concentration range while achieving a de-sired net accumulation of calcium. The method includes determining the dosage of phosphorus binder that will achieve pre-dialysis serum phosphorus concentration of the patient that is within the desired concentration range while accounting for the change in the amount of phosphorus removed by the dialysis treatment when the pre- dialysis serum phosphorus concentration of the patient is within the desired concentration range, determining a dialysate calcium concentration that will result in the desired net accumulation of calcium over a complete dialysis cycle, and dialyzing the patient with a dialysate containing a calcium concentration based upon that determination.

La présente invention concerne un procédé de détermination dun dosage de liant du phosphore pour un patient subissant un traitement par dialyse en vue dobtenir une concentration en phosphore sérique avant la dialyse dans une plage de concentrations souhaitée tout en atteignant une accumulation nette souhaitée de calcium. Le procédé comprend la détermination du dosage de liant du phosphore qui permettra datteindre, chez le patient et avant la dialyse, une concentration en phosphore sérique qui se trouve dans une plage de concentrations souhaitée tout en compensant la modification de la quantité de phosphore éliminé par le traitement par dialyse lorsque la concentration en phosphore sérique avant la dialyse chez le patient se trouve dans une plage de concentrations souhaitée, la détermination dune concentration de calcium dans le dialysat qui résultera en laccumulation nette souhaitée de calcium sur un cycle complet de dialyse, et la dialyse du patient avec un dialysat contenant une concentration de calcium basée sur cette détermination.

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