G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/86 (2006.01) C12Q 1/56 (2006.01)
Patent
CA 2744340
Provided is a method of measuring coagulation activity of a PEGylated blood coagulation factor through a silica based activated partial thromboplastin time (APTT) assay. A PEGylated blood coagulation factor was found to display reduced activity in a silica-based APTT assay, and the addition of PEG to the APTT reaction mixture was shown to restore its activity. Methods for determining the coagulation activity of a PEGylated blood coagulation factor in an APTT assay are provided.
La présente invention concerne un procédé de mesure de lactivité de coagulation dun facteur de coagulation sanguine pégylé par un essai de temps de thromboplastine partielle activée (APTT) à base de silice. Il a été observé quun facteur de coagulation sanguine pégylé présente une activité réduite dans un essai APTT à base de silice, et il a été démontré que lajout de PEG au mélange de réaction APTT restaure son activité. La présente invention concerne des procédés pour déterminer lactivité de coagulation dun facteur de coagulation sanguine pégylé dans un essai APTT.
Apeler Heiner
Ramsey Philip
Tang Liang
Bayer Healthcare Llc
Mbm Intellectual Property Law Llp
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