Method of diagnosing a genetic susceptibility for bone damage

C - Chemistry – Metallurgy – 12 – Q

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Details

C12Q 1/68 (2006.01) A01K 67/027 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2528143

The present invention relates to the identification of a novel nucleotide polymorphism in the inhibin beta-A (INHBA) gene and the exploitation of this nucleotide polymorphism in the diagnosis of susceptibility to bone damage, particularly fracture. Also provided are transgenic non-human animals comprising the polynucleotides of the present invention and methods and kits for diagnosing and/or determining susceptibility to bone damage.

La présente invention concerne l'identification d'un nouveau polymorphisme nucléotidique dans le gène de la bêta inhibine A (INHBA) et l'exploitation dudit polymorphisme nucléotidique dans le diagnostic d'une susceptibilité à des lésions osseuses, notamment à la fracture. L'invention concerne également des animaux transgéniques non humains comprenant les polynucléotides selon la présente invention ainsi que des méthodes et des matériels permettant de diagnostiquer et/ou de déterminer une susceptibilité à des lésions osseuses.

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