Method of diagnosing and monitoring malignant breast carcinomas

Details Method of diagnosing and monitoring malignant breast carcinomas Method of diagnosing and monitoring malignant breast carcinomas

G - Physics

01

N

G01N 33/574 (2006.01) G01N 33/48 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2363566

A panel of biomarkers for the diagnosis and treatment of breast cancer was examined in the saliva of a cohort of 1) healthy women, 2) women with benign lesions of the breast and 3) women with diagnosed breast cancer. Recognized tumor markers c-erbB-2 (erb), cancer antigen 15-3 (CA 15-3), and tumor suppresser oncogene protein 53 (p53) were found in the saliva of all three groups of women. The levels of erb and CA 15-3 in the cancer patients evaluated, however, were significantly higher than the salivary levels of healthy controls and benign tumor patients. Conversely, pantropic p53 levels were higher in controls as compared to those women with breast cancer and those with benign tumors.

On a examiné un panel de marqueurs biologiques, permettant d'établir un diagnostic et de traiter le cancer du sein, dans la salive d'une cohorte : 1) de femmes saines ; 2) de femmes présentant des lésions bénignes du sein ; et 3) de femmes chez lesquelles un cancer du sein a été diagnostiqué. On a trouvé des marqueurs tumoraux reconnus, c-erbB-2 (erb), un antigène du cancer 15-3 (CA 15-3) et une protéine oncogène de suppression de tumeurs 53 (p53) dans la salive des trois groupes de femmes. Les niveaux d'erb et de CA 15-3 dans la salive des patientes cancéreuses étaient cependant bien plus élevés que dans la salive des sujets sains et des patientes atteintes de tumeurs bénignes. En revanche, les niveaux de p53 pantrope étaient plus élevés chez les sujets sains que chez les femmes souffrant d'un cancer du sein et chez celles atteintes d'une tumeur bénigne.

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