Method of diagnosing and/or predicting the development of an...

C - Chemistry – Metallurgy – 12 – Q

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Details

C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2579705

The present invention relates to methods for diagnosing an allergic disorder, predicting the development of an allergic disorder in an animal, monitoring the progress of therapy targeted at an allergic disorder, classification of the allergic disorder into one or more clinical/immunological phenotypes, and/or determining the potential responsiveness of individual animals suffering from or at risk of an allergic disorder to particular forms of therapy. In particular, the present invention relates to a method of diagnosing and/or predicting the development of an allergic disorder in an animal, comprising the step of analysing a biological sample from the animal to determine the level of activation of one or more allergy-associated genes, in which the level of activation is diagnostic of the allergic disorder or predictive of the relative risk for the development of an allergic disorder in the animal.

L'invention concerne des méthodes de diagnostic d'une affection allergique, de prédiction du développement d'une affection allergique chez un animal, de surveillance du déroulement de la thérapie dirigée contre une affection allergique, de classification de l'affection allergique en un ou plusieurs phénotypes cliniques/immunologiques, et/ou de détermination de la réactivité potentielle à des formes particulières de thérapie d'animaux individuels souffrant d'une affection allergique ou prédisposés à une affection allergique. L'invention porte notamment sur une méthode de diagnostic et/ou de prédiction du développement d'une affection allergique chez un animal, qui consiste à analyser un échantillon biologique provenant de l'animal pour déterminer le niveau d'activation d'un ou plusieurs gènes associés à l'allergie, étape dans laquelle le niveau d'activation constitue un diagnostic du trouble allergique ou une prédiction du risque relatif de développement d'une affection allergique chez l'animal.

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