C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C12Q 1/02 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2143261
The present invention relates to a method of diagnosing cancer, precancerous state, and susceptibility to other forms of diseases, by use of a molecular marker, interferon-regulatory factor-1 (IRF-1). The method is characterized in that IRF-1-specific RNA is analysed in a sample obtained from blood or other biopsy material, preferably by reverse transcrip- tion/polymerase chain reaction. The invention is based on the unexpected finding that a novel mechanism of inactiva- tion of the tumor suppressor gene IRF-1 plays a crucial role e.g. in hematopoietic malignan- cies. An unusual exon skipping leads to RNA molecules which lack exon 2 or exons 2 and 3. The relative amounts of full-length RNA and shortened RNA molecules are significantly different in samples obtained from tumor patients as compared to healthy donors.
Harada Hisashi
Taniguchi Tadatsugu
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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