C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07K 14/47 (2006.01) C12N 15/12 (2006.01) G01N 33/53 (2006.01) G01N 33/564 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2390387
This invention provides a method for diagnosing rheumatoid arthritis which comprises digesting human genomic DNA with a restriction enzyme EcoRI and detecting an about 7 kb DNA fragment which hybridizes with a probe having the base sequence of the position 159-424 in SEQ ID NO: 1, or which comprises digesting human genomic DNA with a restriction enzyme Dral and detecting an about 1.5 kb DNA fragment which hybrizes with a probe having the base sequence of the position 159-424 in SEQ ID NO: 1. The invention also provides a method for diagnosing rheumatoid arthritis which comprises stimulating the peripheral blood mononuclear cells in a subject with phorbol 12-myristate 13-acetate (PMA) and/or phytohemagglutinin (PHA), and comparing the amount of expression product in the peripheral blood mononuclear cells with the amount of the same product in the peripheral blood mononuclear cells in a healthy person stimulated by PMA and/or PHA, wherein the expression product is expressed from the base sequence of at the least 689-760 position in SEQ ID NO: 1.
Konishi Yoshitake
Shiozawa Shunichi
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Shiozawa Shunichi
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