Method of diagnosis and treatment for asthma based on...

A - Human Necessities – 61 – K

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A61K 31/00 (2006.01) A61K 31/519 (2006.01) A61K 31/553 (2006.01) A61P 11/06 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2532203

Methods for diagnosis of asthma or a susceptibility to asthma based on detection of at-risk haplotypes associated with MAP3K9 are disclosed. Also methods for treatment of asthma or a susceptibility to asthma based on detection of at-risk haplotypes associated with MAP3K9 are disclosed. In particular, pathway targeting for treating individuals who are at-risk of developing asmtha are described. In certain aspects, MLK1 inhibitors are used in treatment methods.

L'invention concerne des méthodes de diagnostic de l'asthme ou d'une susceptibilité à l'asthme reposant sur la détection d'haplotypes à risque associés à MAP3K9. Cette invention a aussi trait à des méthodes de traitement de l'asthme ou d'une susceptibilité à l'asthme reposant sur la détection d'haplotypes à risque associés à MAP3K9. Notamment, ladite invention porte sur le ciblage de voies dans le traitement d'individus qui présentent un risque de développer de l'asthme. Selon certains aspects, des inhibiteurs MLK1 sont utilisés dans les méthodes de traitement.

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