Method of diagnosis and treatment of atherosclerosis using...

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G01N 33/53 (2006.01) G01N 33/577 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2239092

Methods of use of anti-cholesterol antibodies are described for diagnosis and treatment of atherosclerosis. In one embodiment of the invention, anti- cholesterol antibodies are used to assay samples drawn from atherosclerotic lesions for the amount of VLDL, IDL and LDL, but not HDL molecules. In another embodiment of the invention, the anti-cholesterol antibodies are used as fusiogens to promote fusion of lipoprotein molecules and of liposomes, to promote clearance of cholesterol from the body.

Méthodes d'utilisation d'anticorps anti-cholestérol destinées au diagnostic et au traitement de l'athérosclérose. Dans un mode de réalisation de l'invention, on utilise des anticorps anti-cholestérol afin de doser des échantillons prélevés sur des lésions athéroscléreuses afin de déterminer la quantité de molécules de lipoprotéines de très basse densité, de lipoprotéines de densité intermédiaire et de lipoprotéines de faible densité mais pas de lipoproteines de haute densité. Dans un autre mode de réalisation de l'invention, on utilise les anticorps anti-cholestérol en tant que fusiogènes pour stimuler la fusion de molécules de lipoprotéines et de liposomes, de manière à stimuler l'élimination du cholestérol par le corps.

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