Method of diagnosis and treatment of breast lesions

Details Method of diagnosis and treatment of breast lesions Method of diagnosis and treatment of breast lesions

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 51/04 (2006.01)

Patent

CA 2477828

The present invention relates to an apparatus and method for administering diagnostic and therapeutic agents into a breast duct. A thymidine kinase vector may be administered into a breast duct in conjunction with an acycloguanidine compound for enhanced imaging on PET scanning of the breast to detect breast lesions. The thymidine kinase phosphoraylates the acycloguanidine compound to enhance visibility of lesions on PET scan. An acyclic nucleoside compound may be administered into the breast duct to form phosphorylated adducts that phosphorylate DNA and kill thymidine kinase expressing cancer cells.

Cette invention concerne un appareil et une méthode permettant d'administrer des agents diagnostiques et thérapeutiques dans un canal mammaire. Un vecteur de thymidine kinase peut être administré dans un canal mammaire conjointement à un composé acycloguanidine afin d'obtenir une meilleure formation d'image par tomographie par émission de positons (TEP) du sein afin que les lésions mammaires soient détectées. La thymidine kinase phosphoryle le composé acycloguanidine pour renforcer la visibilité des lésions sur une image obtenue par tomographie par émission de positons. Un composé nucléoside acyclique peut être administré dans le canal mammaire pour former des adducts phosphorylés qui phosphorylent l'ADN et tuent les cellules cancéreuses qui expriment la thymidine kinase.

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