C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2586874
The present invention provides methods of diagnosis and prognosis of human chronic lymphocytic leukemia (CLL) in a patient in need thereof and methods to determine IgVHmutational status. The methods of the present invention involve measuring the expression profile of two known genes: LPL and ADAM29; and comparing the ratio of their expression to diagnose the presence of CLL or to prognose the likelihood of developing CLL or the symptoms consistent with CLL.
L'invention concerne des procédés de diagnostic et de pronostic de la leucémie lymphoïde chronique (LLC) chez un patient, ainsi que des procédés de détermination de l'état mutationnel IgVH. Les procédés de l'invention consistent à mesurer le profil d'expression de deux gènes connus: LPL et ADAM29; et à comparer le rapport de leur expression pour diagnostiquer la présence de LLC ou pour pronostiquer le risque de développer la LLC ou des symptômes associés à la LLC.
Davi Frederic
Dighiero Guillaume
Dumas Gerard
Oppezo Pablo
Settegrana Catherine
Assistance Publique-Hopitaux de Paris
Centre National de La Recherche Scientifique
Institut Pasteur
Robic
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