C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/071 (2010.01) C12N 5/073 (2010.01) C12N 5/0735 (2010.01)
Patent
CA 2650561
The invention relates to compositions and methods for treating patients with Demyelinating Diseases and Conditions including Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compositions and methods may also be used for Stroke Rehabilitation and the treatment of pain disorders including Neuropathic Pain and Chemokine-Induced Pain. The compositions comprise one or more pyridazine compounds having a pyridazinyl radical pendant with an aryl or substituted aryl, a heteroaryl or substituted heteroaryl.
L'invention porte sur des compositions et des procédés qui permettent de traiter des patients atteints de maladies et états de démyélénisation, y compris la sclérose en plaques, les traumatismes médullaires, les traumatismes cérébraux et les accidents vasculaires cérébraux. Les compositions et procédés de l'invention peuvent également être utilisés pour la réhabilitation à la suite d'un accident vasculaire cérébral et pour le traitement de la douleur, y compris la douleur neuropathique et la douleur induite par la chémokine. Les compositions de l'invention peuvent comprendre au moins un composé pyridazine comprenant un radical pyridazinyle libre avec un aryle ou un aryle substitué, un hétéroaryle ou un hétéroaryle substitué.
Odorico Jon
Xu Xiaofang
Gowling Lafleur Henderson Llp
Wisconsin Alumni Research Foundation
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