Method of direct identification of compound efficacy at a g...

Details Method of direct identification of compound efficacy at a g... Method of direct identification of compound efficacy at a g...

G - Physics

01

N

G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2338543

Disclosed herein are techniques for directly identifying candidate compounds as agonists. partial agonists and/or, most preferably, inverse agonists, to endogenous, constitutively activated orphan G protein- coupled receptors. Such directly identified compounds can be utilized, most preferably, in pharmaceutical compositions.

La présente invention concerne des procédés permettant l'identification directe de composés présentant un intérêt potentiel comme agonistes, agonistes partiels et/ou, de préférence, agonistes inverses de récepteurs orphelins endogènes à activation constitutive couplés à la protéine G. Ces composés d'identification directe sont utilisés, de préférence, dans des compositions pharmaceutiques.

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