Method of dna vaccination

Details Method of dna vaccination Method of dna vaccination

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 39/04 (2006.01) A61K 39/39 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2341544

A method of vaccinating a mammal against a disease state, comprising administrating to said mammal, within an appropriate vector, a nucleotide sequence encoding an antigenic peptide associated with the disease state; additionally administering to said mammal a compound which enhances both humoral and cellular immune responses initiated by the antigenic peptide, the compound being selected from the list contained herein, wherein the compound is preferably Tucaresol or a physiologically acceptable salt or ester thereof, where appropriate.

L'invention concerne un procédé de vaccination d'un mammifère contre une maladie, comprenant les étapes consistant à administrer à ce mammifère, dans un vecteur approprié, une séquence nucléotidique codant pour un peptide antigénique associé à ladite maladie, à administrer en outre à ce mammifère un composé favorisant les réponses immunes à la fois humorales et cellulaires, amorcées par le peptide antigénique, ce composé étant choisi dans la liste énoncée dans le brevet et étant, de préférence, du Tucaresol, ou le cas échéant, un sel ou ester de celui-ci, acceptable sur le plan physiologique.

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