A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2634377
The present invention relates to methods of eliciting an immune response by use of a prime-boost schedule for delivering a polynucleotide encoding a heterologous non-self antigen. In particu-lar, the invention relates to a prime-boost schedule wherein the prim-ing polynucleotide composition is delivered by an adenoviral vector, and the boosting polynucleotide composition is coated on or incorpo-rated in a particle and is administered by a particle acceleration device.
L'invention se rapporte à des procédés pour induire une réponse immunitaire au moyen d'un protocole de primo-vaccination/rappel pour administrer un polynucléotide codant un antigène hétérologue du non-soi. Cette invention concerne en particulier un protocole de primo-vaccination/rappel au cours duquel la composition polynucléotidique de primo-vaccination est administrée par l'intermédiaire d'un vecteur adénoviral, et la composition polynucléotidique de rappel est appliquée sur une particule ou incorporée dans une particule et administrée au moyen d'un accélérateur de particules.
Barber Karen A.
Baxter Gillian Margaret
Brett Sara Jane
Hamblin Paul Andrew
Tite John Philip
Glaxo Group Limited
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
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