Method of encapsulating biologically active materials in...

Details Method of encapsulating biologically active materials in... Method of encapsulating biologically active materials in...

A - Human Necessities

61

K

167/163

A61K 9/10 (2006.01) A61K 9/127 (2006.01)

Patent

CA 1205383

AN IMPROVED METHOD OF ENCAPSULATING BIOLOGICALLY ACTIVE MATERIALS IN MULTILLAMELLAR LIPID VESICLES (MLV) ABSTRACT This invention provides an improved procedure for producing large multilamellar lipid vesicles (MLV), which may be used to encapsulate a biologically active material, particularly lipophilic substances. According to this invention, a lipid film is formed on inert, solid contact masses within a vessel, by evaporating an organic solvent therefrom. Subsequent agitation in the presence of an aqueous liquid, followed by a period in which the vessel remains undisturbed yields the multilamellar vesicles. The procedure permits the encapsulation of both hydrophilic and lipophilic materials.

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