A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/18 (2006.01) A61K 38/22 (2006.01)
Patent
CA 2492434
Methods are described for the enhancement and/or induction of migration of neural stem cells or neuronal progenitor cells. Multipotent neural stem cells are exposed to erythropoietin which enhances the migration of multipotent neural stem cells and neuronal progenitor cells. The erythropoietin may be exogenously applied to the multipotent neural stem cells, or alternatively, the cells can be subjected to hypoxic insult which induces the cells to express erythropoietin. In a preferred embodiment, additional growth factors, such as EGF and prolactin, are utilized.
L'invention concerne des procédés permettant d'accroître et/ou d'induire une migration de cellules souches neurales ou de cellules progénitrices neuronales. Des cellules souches neurales multipotentes sont exposées à l'érythropoiétine accroissant la migration desdites cellules et des cellules progénitrices neuronales. L'érythropoiétine peut être appliquée de manière exogène sur les cellules souches neurales multipotentes ou, de manière alternative, les cellules peuvent être soumises à une agression hypoxique induisant l'expression de l'érythropoiétine par les cellules. Dans un mode de réalisation préféré, des facteurs de croissance supplémentaires, tels que le facteur de croissance de l'épiderme (EGF) et la prolactine, sont utilisés.
Andersen Linda B.
Shingo Tetsuro
Weiss Samuel
Marks & Clerk
Stem Cell Therapeutics Inc.
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