Method of enhancing and/or prolonging expression of a gene...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/67 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2144659

The expression of polynucleotide introduced into a cell by means of a targeted complex of the polynucleotide linked to a cell-specific binding agent can be enhanced and prolonged by inhibiting translocation or fusion of endosomes to lysosomes.

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