C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/077 (2010.01) C12N 5/071 (2010.01) A61K 35/12 (2006.01) A61K 38/19 (2006.01) A61L 27/38 (2006.01)
Patent
CA 2581237
The present invention relates to methods of enhancing proliferation and/or survival of mesenchymal precursor cells (MPC) and/or progeny derived therefrom in vitro or in vivo comprising exposing the MPC or progeny to SDF-1 or analog thereof. The invention also relates to compositions comprising isolated MPCs or progeny derived therefrom and SDF-1or analogues thereof. The present invention also relates to using such methods and compositions for ex vivo or in vivo bone formation in mammals.
La présente invention concerne des procédés d'accroissement de la prolifération et/ou de la survie de cellules précurseurs mésenchymateuses (MPC) et/ou de la lignée dérivée de celles-ci in vitro ou in vivo, comprenant d'exposer les MPC ou leur lignée au SDF-1 ou à un analogue de celui-ci. L'invention concerne également des compositions comprenant des MPC isolées ou des lignées dérivées de celles-ci et du SDF-1 ou des analogues de celui-ci. La présente invention concerne également l'utilisation de tels procédés et compositions pour la formation osseuse ex vivo ou in vivo chez des mammifères.
Gronthos Stan
Zannettino Andrew Christopher William
Angioblast Systems Inc.
Bcf Llp
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